ื”ืขื“ืคืชื›ื ืขื•ื“ื›ื ื” ืขื‘ื•ืจ ื”ืžืคื’ืฉ ื”ื–ื”. ื›ื“ื™ ืœืฉื ื•ืช ืืช ื”ื’ื“ืจืช ื”ื—ืฉื‘ื•ืŸ ืœืฆืžื™ืชื•ืช, ืขื‘ืจื• ืืœ
ืœื”ื–ื›ื™ืจื›ื, ื ื™ืชืŸ ืœืขื“ื›ืŸ ืืช ื”ืžื“ื™ื ื” ืื• ื”ืฉืคื” ื”ืžื•ืขื“ืคื•ืช ืขืœื™ื›ื ื‘ื›ืœ ืขืช ื‘
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ืงื•ืœื’ืŸ ืขื•ืœื” ืœื›ื•ืชืจื•ืช ืœืื—ืจื•ื ื”. ื‘ื™ืŸ ื”ื”ืฉืคืขื•ืช ื”ืžื™ื•ื—ืกื•ืช ืœื• ืขื™ื›ื•ื‘ ื”ื–ื“ืงื ื•ืช ื•ื”ืขื ืงืช ืชื—ื•ืฉืช ื ืขื•ืจื™ื. ืงืจื•ื‘ ืœื•ื•ื“ืื™ ืฉืจืื™ืชื ืžื•ืฆืจื™ื ืขื ืงื•ืœื’ืŸ ืขืœ ืžื“ืคื™ื ืขื ืžื•ืฆืจื™ ืื™ืคื•ืจ, ื˜ื™ืคื•ื— ืขื•ืจ ืื• ืชื•ืกืคื™ ืชื–ื•ื ื”. ืื‘ืœ ืžื”ื• ืงื•ืœื’ืŸ, ื•ืœืžื” ื”ื•ื ื›ืœ-ื›ืš ืคื•ืคื•ืœืจื™?

ืžื”ื• ืงื•ืœื’ืŸ?

ืงื•ืœื’ืŸ ื”ื•ื ื”ื—ืœื‘ื•ืŸ ื”ื ืคื•ืฅ ื‘ื™ื•ืชืจ ื‘ื’ื•ืฃ ื”ืื“ื. ื”ื•ื ืžืฆื•ื™ ื‘ืขื•ืจ, ื‘ืฉืจื™ืจื™ื, ื‘ื’ื™ื“ื™ื ื•ื‘ืจืฆื•ืขื•ืช. ืงื•ืœื’ืŸ ื”ื•ื ื—ืœื‘ื•ืŸ ืžื•ืจื›ื‘ ื”ืžื™ื•ืฆืจ ืžื—ื•ืžืฆื•ืช ืืžื™ื ื• ื›ืžื• ื’ืœื™ืฆื™ืŸ, ืคืจื•ืœื™ืŸ, ื”ื™ื“ืจื•ืงืกื™-ืคืจื•ืœื™ืŸ ื•ืืจื’ื™ื ื™ืŸ. ื”ื•ื ื–ื” ืฉืžืขื ื™ืง ืœืขื•ืจ ืฉืœื ื• ืืช ื”ื’ืžื™ืฉื•ืช ื•ื”ื—ื•ื–ืง ืฉืœื•. 

ื›ื›ืœ ืฉืื ื—ื ื• ืžื–ื“ืงื ื™ื, ื—ืœื” ื™ืจื™ื“ื” ื˜ื‘ืขื™ืช ื‘ื™ื™ืฆื•ืจ ื”ืงื•ืœื’ืŸ. ื–ื” ืขืœื•ืœ ืœื”ื•ื‘ื™ืœ ืœื”ื•ืคืขืช ืงืžื˜ื™ื, ืœืขื•ืจ ืจืคื•ื™ ื•ืืคื™ืœื• ืœื›ืื‘ื™ ืžืคืจืงื™ื. ืจื‘ื™ื ืžื—ืคืฉื™ื ืžื•ืฆืจื™ื ืขื ืงื•ืœื’ืŸ ื›ืฉื”ื ืžื‘ื—ื™ื ื™ื ื‘ืชืกืžื™ื ื™ื ื”ืืœื” ืฉืœ ื™ืจื™ื“ื” ื‘ื™ื™ืฆื•ืจ ื”ืงื•ืœื’ืŸ. 

ืงื•ืœื’ืŸ ืžื•ืคืง ืžื”ืขื•ืจ ื•ื”ืขืฆืžื•ืช ืฉืœ ื‘ืงืจ ื•ื—ื–ื™ืจื™ื, ื•ืœืคืขืžื™ื ืžืงืฉืงืฉื™ ื“ื’ื™ื ืื• ืงืœื™ืคื•ืช ื‘ื™ืฆื™ื. ื”ื•ื ืžื’ื™ืข ื‘ืขื™ืงืจ ืžืจืงืžืช ื”ื—ื™ื‘ื•ืจ ืฉืœ ื‘ืงืจ. ืงื•ืœื’ืŸ ื™ืžื™ ืžื’ื™ืข ืžื“ื’ื™ื ืื• ืžื‘ืขืœื™ ื—ื™ื™ื ื™ืžื™ื™ื ืื—ืจื™ื. ืจืงืžื•ืช ื”ื—ื™ื‘ื•ืจ ื ืœืงื—ื•ืช ืžืชื•ืฆืจื™ ืœื•ื•ืื™ ืžืŸ ื”ื—ื™ ื•ื ื˜ื—ื ื•ืช ืœืื‘ืงื” ื“ืงื”. ื›ืš ืžืชืงื‘ืœ ื”ืงื•ืœื’ืŸ ืฉืื ื—ื ื• ืงื•ื ื™ื ื‘ื—ื ื•ื™ื•ืช.

ื ื™ืชืŸ ืœืžืฆื•ื ืงื•ืœื’ืŸ ืžืขื•ื‘ื“ ื‘ืชื•ืกืคื™ื, ืชื—ืœื™ื‘ื™ื ื•ืžื•ืฆืจื™ ืงื•ืกืžื˜ื™ืงื” ืื—ืจื™ื. ื”ืฉื™ืžื•ืฉ ื‘ืงื•ืœื’ืŸ ื”ืชื—ื™ืœ ืžืžื•ืฆืจื™ ืงื•ืกืžื˜ื™ืงื”, ื•ื‘ื”ืžืฉืš ื”ื•ื ื’ื ื”ืคืš ืœืชื•ืกืฃ ืคื•ืคื•ืœืจื™, ืœืื—ืจ ืฉืฆืจื›ื ื™ื ื”ื‘ื—ื™ื ื• ื‘ืชื•ืฆืื•ืช ืฉืœ ืฉื™ืžื•ืฉ ื‘ืžื•ืฆืจื™ ืงื•ืกืžื˜ื™ืงื” ืขื ืงื•ืœื’ืŸ.

ืžื”ื• ืงื•ืœื’ืŸ ื˜ื‘ืขื•ื ื™?

ืงื•ืœื’ืŸ ื˜ื‘ืขื•ื ื™ ื”ื•ื ืชื—ืœื™ืฃ ืœืœื ืžื•ืฆืจื™ื ืžืŸ ื”ื—ื™. ืœืขืชื™ื ืงืจื•ื‘ื•ืช ืงื•ืœื’ืŸ ื˜ื‘ืขื•ื ื™ ืžื™ื•ืฆืจ ืžืฉืžืจื™ื ื‘ืฉื Pichia pastoris. ืงื•ืœื’ืŸ ื˜ื‘ืขื•ื ื™ ื”ื•ื ืขื“ื™ื™ืŸ ื ืžืฆื ื‘ืฉืœื‘ื™ ืคื™ืชื•ื— ืžื•ืงื“ืžื™ื.1 ืฉืžืจื™ P. pastoris ื”ื ื”ืžื™ืงืจื•-ืื•ืจื’ื ื™ื–ื ื”ื™ืขื™ืœ ื•ื”ื ืคื•ืฅ ื‘ื™ื•ืชืจ ืœื™ื™ืฆื•ืจ ืชื•ืกืคื™ ืงื•ืœื’ืŸ ื˜ื‘ืขื•ื ื™ ืื™ื›ื•ืชื™ื™ื.

ื›ื™ื•ื ืœื ืงืœ ืœืžืฆื•ื ืชื•ืกืคื™ ืงื•ืœื’ืŸ ื˜ื‘ืขื•ื ื™. ืกื‘ื™ืจ ื™ื•ืชืจ ืฉืชืฆืœื™ื—ื• ืœืžืฆื•ื ืชื•ืกืคื™ื ื‘ืฉื "ื‘ื•ึผืกื˜ืจื™ื ื˜ื‘ืขื•ื ื™ื™ื ืฉืœ ืงื•ืœื’ืŸ". ื ื™ืชืŸ ืœืจืื•ืช ืฉืขืœ ื”ืืจื™ื–ื•ืช ืฉืœ ืจื•ื‘ ืชื•ืกืคื™ ื”ืงื•ืœื’ืŸ ื”ื˜ื‘ืขื•ื ื™ื™ื ื›ืชื•ื‘ "ื‘ื•ึผืกื˜ืจ ืฉืœ ืงื•ืœื’ืŸ" ืื• "ืชื•ืกืฃ ืœื‘ื ื™ื™ืช ืงื•ืœื’ืŸ". ื”ืชื›ืฉื™ืจื™ื ื”ืืœื” ืžื›ื™ืœื™ื ืžืจื›ื™ื‘ื™ื ืฉืขื•ื–ืจื™ื ืœื”ื’ื“ื™ืœ ืืช ื™ื™ืฆื•ืจ ื”ืงื•ืœื’ืŸ ื”ื˜ื‘ืขื™ ื‘ื’ื•ืฃ. 

ืืžื ื ืงืฉื” ื™ื•ืชืจ ืœืžืฆื•ื ืชื•ืกืคื™ื ื˜ื‘ืขื•ื ื™ื™ื ืฉืœ ืงื•ืœื’ืŸ ืœื ื˜ื™ืœื” ืคื•ืžื™ืช, ืื‘ืœ ืงื™ื™ืžื™ื ืžื•ืฆืจื™ ืงื•ืกืžื˜ื™ืงื” ืจื‘ื™ื ืขื ืงื•ืœื’ืŸ ื˜ื‘ืขื•ื ื™. ื”ืงืคื™ื“ื• ืชืžื™ื“ ืœืงืจื•ื ืืช ืจืฉื™ืžืช ื”ืžืจื›ื™ื‘ื™ื ื•ืชื•ื•ื™ืช ื”ืžื•ืฆืจ ื›ืฉืืชื ืžื—ืคืฉื™ื ืžื•ืฆืจ ื˜ื‘ืขื•ื ื™, ื›ื“ื™ ืœื•ื•ื“ื ืฉื™ืฉ ืœืžื•ืฆืจ ื–ื” ืชื• ื˜ื‘ืขื•ื ื™ ื•ื”ื•ื ืœื ื ื‘ื“ืง ืขืœ ื‘ืขืœื™ ื—ื™ื™ื.

ืžื” ื’ื•ืจื ืœืื•ื‘ื“ืŸ ืงื•ืœื’ืŸ?

ื’ื•ืจืžื™ื ืจื‘ื™ื ื™ื›ื•ืœื™ื ืœื”ืื™ืฅ ืื•ื‘ื“ืŸ ืงื•ืœื’ืŸ ื‘ื’ื•ืฃ. ืื ื—ื ื• ืžืื‘ื“ื™ื ืงื•ืœื’ืŸ ื‘ืื•ืคืŸ ื˜ื‘ืขื™ ื›ืชื•ืฆืื” ืžื”ื–ื“ืงื ื•ืช, ืื‘ืœ ื’ื ื’ื•ืจืžื™ื ืกื‘ื™ื‘ืชื™ื™ื ื•ืื•ืจื—ื•ืช ื—ื™ื™ื ืžืกื•ื™ืžื™ื ืชื•ืจืžื™ื ืœืื•ื‘ื“ืŸ ืงื•ืœื’ืŸ. 

ื—ืฉื™ืคื” ืœืงืจื™ื ืช ื”ืขืœ-ืกื’ื•ืœ ืฉืœ ื”ืฉืžืฉ ื’ื•ืจืžืช ืœืคื’ื™ืขื” ื‘ืขื•ืจ, ื•ื‘ืžื”ืœืš ื”ื–ืžืŸ ื”ื™ื ืชื‘ื™ื ืœื™ืจื™ื“ื” ื‘ื™ื›ื•ืœืชื• ืฉืœ ื”ืขื•ืจ ืœื™ื™ืฆืจ ืงื•ืœื’ืŸ. ื–ืืช ืื—ืช ื”ืกื™ื‘ื•ืช ืœื›ืš ืฉื—ื™ื™ื‘ื™ื ืชืžื™ื“ ืœื”ืฉืชืžืฉ ื‘ืžืกื ืŸ ืงืจื™ื ื”

ืงื•ืœื’ืŸ ืžืฉืคื™ืข ื’ื ืขืœ ื”ืขืฆืžื•ืช ืฉืœื ื•. ื›ื›ืœ ืฉืื ื—ื ื• ืžื–ื“ืงื ื™ื, ื”ืงื•ืœื’ืŸ ื‘ืžืขืจื›ืช ื”ืฉืœื“ ื ื”ื™ื” ืคื—ื•ืช ืืžื™ืŸ, ืžื” ืฉืžื•ื‘ื™ืœ ืœื™ืจื™ื“ื” ื‘ื—ื•ื–ืง ื”ืขืฆื.2 

ืื•ืจื—ื•ืช ื—ื™ื™ื ื›ืžื• ืขื™ืฉื•ืŸ ืกื™ื’ืจื™ื•ืช, ืฉืชื™ื™ืช ืืœื›ื•ื”ื•ืœ ื•ืืคื™ืœื• ืฆืจื™ื›ื” ืžื•ืคืจื–ืช ืฉืœ ืกื•ื›ืจ ืžื•ึผืกืฃ ืื• ืžื–ื•ื ื•ืช ื‘ื“ืจื’ืช ืขื™ื‘ื•ื“ ื’ื‘ื•ื”ื” ืขืœื•ืœื™ื ืœืคื’ื•ืข ื‘ื™ื™ืฆื•ืจ ื”ืงื•ืœื’ืŸ ื•ื‘ืžื ื’ื ื•ื ื™ ื”ืฉื™ืงื•ื ืฉืœ ื”ื’ื•ืฃ. 

ื™ื™ืฆื•ืจ ืงื•ืœื’ืŸ

ื”ื’ื•ืฃ ืฉืœื ื• ืžื™ื™ืฆืจ ืงื•ืœื’ืŸ ื‘ืื•ืคืŸ ื˜ื‘ืขื™. ืืžื ื ื˜ื‘ืขื•ื ื™ื ืœื ื–ืงื•ืงื™ื ืชื•ืกืคื™ ืงื•ืœื’ืŸ, ืื‘ืœ ื ืจืื” ืฉืื™ืŸ ืฉื•ื ื—ืกืจื•ื ื•ืช ืœื”ื•ืกืคืชื ืœืฉื’ืจืช ื”ื™ื•ื. ื”ืงืคื™ื“ื• ืชืžื™ื“ ืœื”ืชื™ื™ืขืฅ ืขื ื”ืจื•ืคื ื”ืžื˜ืคืœ ืฉืœื›ื ืœืคื ื™ ืฉื™ื ื•ื™ ืฉื’ืจืช ื”ืชื•ืกืคื™ื ืื• ื”ื•ืกืคืช ืชื•ืกืคื™ื ื—ื“ืฉื™ื. 

ื”ื’ื“ืœืช ืฆืจื™ื›ืช ื”ื—ืœื‘ื•ืŸ ืขืฉื•ื™ื” ืœืชืจื•ื ืœื”ื’ื‘ืจืช ื™ื™ืฆื•ืจ ื”ืงื•ืœื’ืŸ โ€” ืื›ื™ืœื” ืฉืœ ืžื’ื•ื•ืŸ ืžืงื•ืจื•ืช ื—ืœื‘ื•ืŸ ื‘ืžื”ืœืš ื”ื™ื•ื ืžื‘ื˜ื™ื—ื” ืฉืชืงื‘ืœื• ืืช ื›ืœ ื—ื•ืžืฆื•ืช ื”ืืžื™ื ื• ืœื”ืŸ ื”ื’ื•ืฃ ื–ืงื•ืง ื›ื“ื™ ืœื”ืžืฉื™ืš ื•ืœื™ื™ืฆืจ ืงื•ืœื’ืŸ. ืœื‘ื•ื’ืจื™ื ื‘ืจื™ืื™ื ืžื•ืžืœืฅ ืœืฉืื•ืฃ ืœืฆืจื™ื›ืช 0.8 ื’ืจื ื—ืœื‘ื•ืŸ ืœืงื™ืœื•ื’ืจื ืžืฉืงืœ ื’ื•ืฃ ื‘ื™ื•ื ืœืคื—ื•ืช, ื›ืœื•ืžืจ 0.36 ื’ืจื ื—ืœื‘ื•ืŸ ืœืœื™ื‘ืจื”. 

ืฉืงืœื• ืœื”ื•ืกื™ืฃ ืœืชื–ื•ื ื” ื”ื˜ื‘ืขื•ื ื™ืช ืฉืœื›ื ืืช ืžืงื•ืจื•ืช ื”ื—ืœื‘ื•ืŸ ื”ื‘ืื™ื ื•ื’ื ืžืงื•ืจื•ืช ื—ืœื‘ื•ืŸ ืฆืžื—ื™ื™ื ื ื•ืกืคื™ื, ื›ื“ื™ ืœืกืคืง ืืช ื”ืฆืจื›ื™ื ื”ืชื–ื•ื ืชื™ื™ื ืฉืœื›ื ื•ืœืกื™ื™ืข ืœื™ื™ืฆื•ืจ ื”ืงื•ืœื’ืŸ ื”ื˜ื‘ืขื™ ื‘ื’ื•ืฃ: 

ื‘ื•ึผืกื˜ืจื™ื ืฉืœ ืงื•ืœื’ืŸ

ื‘ื•ึผืกื˜ืจื™ื ืฉืœ ืงื•ืœื’ืŸ ื”ื ื—ื•ืžืจื™ื ืžื–ื™ื ื™ื ืฉืชื•ืจืžื™ื ืœื”ื’ื‘ืจืช ื™ื™ืฆื•ืจ ื”ืงื•ืœื’ืŸ ื”ื˜ื‘ืขื™ ื‘ื’ื•ืฃ. ื”ื•ืกืคืช ื”ื‘ื•ึผืกื˜ืจื™ื ื”ืืœื” ืœืชืคืจื™ื˜, ื‘ืฉื™ืœื•ื‘ ืขื ื—ืœื‘ื•ื ื™ื ืžืžืงื•ืจ ืฆืžื—ื™, ืขืฉื•ื™ื” ืœืชืจื•ื ืœื”ื’ื‘ืจืช ื™ื™ืฆื•ืจ ื”ืงื•ืœื’ืŸ. ืืžื ื ื ื“ืจืฉื™ื ืžื—ืงืจื™ื ื ื•ืกืคื™ื ื‘ื ื•ืฉื ื–ื”, ืื‘ืœ ื‘ื™ืŸ ื”ื—ื•ืžืจื™ื ื”ืžื–ื™ื ื™ื ืฉืขืฉื•ื™ื™ื ืœืชืจื•ื ืœื”ื’ื‘ืจืช ื™ื™ืฆื•ืจ ื”ืงื•ืœื’ืŸ ืืฆืœ ื˜ื‘ืขื•ื ื™ื ื•ื™ื˜ืžื™ืŸ C, ื—ื•ืžืฆื•ืช ืืžื™ื ื•, ื ื—ื•ืฉืช ื•ื ื•ื’ื“ื™ ื—ืžืฆื•ืŸ.

ื•ื™ื˜ืžื™ืŸ C

ื•ื™ื˜ืžื™ืŸ C ื”ื•ื ืื—ื“ ื”ื—ื•ืžืจื™ื ื”ืžื–ื™ื ื™ื ื”ื—ืฉื•ื‘ื™ื ื‘ื™ื•ืชืจ ืœื™ื™ืฆื•ืจ ืงื•ืœื’ืŸ. ื”ื•ื ืžืกื™ื™ืข ืœืฉืงื ื•ืœืจืคื ืจืงืžื•ืช ื—ื™ื‘ื•ืจ.3 ื”ื•ื ื’ื ื ื•ื’ื“ ื—ืžืฆื•ืŸ ืจื‘-ืขื•ืฆืžื” ื”ืขื•ื–ืจ ืœื”ื’ืŸ ืขืœ ื”ืชืื™ื ืžืคื ื™ ื ื–ืงื™ ื”ืจื“ื™ืงืœื™ื ื”ื—ื•ืคืฉื™ื™ื. ื”ื’ื•ืฃ ืฉืœื ื• ืœื ืžืกื•ื’ืœ ืœื™ื™ืฆืจ ื•ื™ื˜ืžื™ืŸ C, ื›ืš ืฉืื ื• ื—ื™ื™ื‘ื™ื ืœืงื‘ืœ ืื•ืชื• ืžื”ืชื–ื•ื ื”. 

ื•ื™ื˜ืžื™ืŸ C ื”ื•ื ื•ื™ื˜ืžื™ืŸ ืžืกื™ืก ืžื™ื ื”ืžืฆื•ื™ ื‘ืคื™ืจื•ืช ื•ื‘ื™ืจืงื•ืช ืจื‘ื™ื. ื‘ื™ืŸ ื”ืžืงื•ืจื•ืช ื”ื˜ื•ื‘ื™ื ืฉืœ ื•ื™ื˜ืžื™ืŸ C:

  • ืชืคื•ื–ื™ื
  • ืคืœืคืœื™ื
  • ื›ืจื•ื‘ ืขืœื™ื
  • ื‘ืจื•ืงื•ืœื™
  • ืงื™ื•ื•ื™
  • ืชื•ืช ืฉื“ื”

ื—ื•ืžืฆื•ืช ืืžื™ื ื•

ื’ื ื—ื•ืžืฆื•ืช ืืžื™ื ื• ืžืžืงื•ืจื•ืช ื—ืœื‘ื•ืŸ ืฆืžื—ื™ื™ื ื™ื›ื•ืœื•ืช ืœืชืจื•ื ืœื‘ื ื™ื™ืช ืงื•ืœื’ืŸ. ื—ื•ืžืฆื•ืช ื”ืืžื™ื ื• ื”ืŸ ืื‘ื ื™ ื”ื‘ื ื™ื™ืŸ ืฉืœ ื”ื—ืœื‘ื•ื ื™ื ื‘ื’ื•ืฃ ืฉืœื ื•. 

ืคืจื•ืœื™ืŸ ื”ื™ื ื—ื•ืžืฆืช ืืžื™ื ื• ื”ื ื“ืจืฉืช ืœื™ื™ืฆื•ืจ ืงื•ืœื’ืŸ. ื ื™ืชืŸ ืœืžืฆื•ื ืคืจื•ืœื™ืŸ ื‘ืžื–ื•ื ื•ืช ื›ืžื• ืคื•ืœื™ ืกื•ื™ื”, ื›ืจื•ื‘ ื•ืคื˜ืจื™ื•ืช. ื’ืœื™ืฆื™ืŸ ื”ื™ื ื—ื•ืžืฆืช ืืžื™ื ื• ื ื•ืกืคืช ื‘ื” ืžืฉืชืžืฉื™ื ื›ื“ื™ ืœืกื™ื™ืข ืœื’ื•ืฃ ืœื™ื™ืฆืจ ืงื•ืœื’ืŸ. ื”ื™ื ืžืฆื•ื™ื” ื‘ืกืคื™ืจื•ืœื™ื ื”ื‘ื’ืจืขื™ื ื™ ื“ืœืขืช ื•ื‘ืคื•ืœื™ ืกื•ื™ื”.

ื ื—ื•ืฉืช

ืœื ื—ื•ืฉืช ืชืคืงื™ื“ ืžืจื›ื–ื™ ื‘ื™ื™ืฆื•ืจ ื”ืงื•ืœื’ืŸ, ื›ื™ ื”ื™ื ืžืกื™ื™ืขืช ืœื™ื™ืฆื•ืจ ืชืื™ ื“ื ืื“ื•ืžื™ื, ืจืงืžืช ืขืฆื ื•ืกื™ื‘ื™ ืจืงืžืช ื—ื™ื‘ื•ืจ ืฉืชื•ืžื›ื™ื ื‘ืจืงืžื•ืช. ื ื™ืชืŸ ืœืžืฆื•ื ื ื—ื•ืฉืช ื‘ื™ืจืงื•ืช ืขืœื™ื ื™ืจื•ืงื™ื, ืฉืขื•ืขื™ืช, ืขื“ืฉื™ื, ืื’ื•ื–ื™ื ื•ื–ืจืขื™ื.4

ื ื•ื’ื“ื™ ื—ืžืฆื•ืŸ

ื›ืœ ื ื•ื’ื“ื™ ื”ื—ืžืฆื•ืŸ ื—ืฉื•ื‘ื™ื ืœื™ื™ืฆื•ืจ ื”ืงื•ืœื’ืŸ, ื›ื™ ื”ื ืขื•ื–ืจื™ื ืœืฉืžื•ืจ ืขืœ ื‘ืจื™ืื•ืช ื”ืชืื™ื ื•ืžื’ื™ื ื™ื ืžืคื ื™ ื ื–ืงื™ ื”ืจื“ื™ืงืœื™ื ื”ื—ื•ืคืฉื™ื™ื. ื‘ื™ืŸ ื”ืžืงื•ืจื•ืช ื”ื˜ื‘ืขื•ื ื™ื™ื ื”ื˜ื•ื‘ื™ื ืฉืœ ื ื•ื’ื“ื™ ื—ืžืฆื•ืŸ ืื•ื›ืžื ื™ื•ืช ื›ื—ื•ืœื•ืช, ืชื•ืชื™ ื’ื•ื’'ื™ ื•ืชื•ืชื™ ืืกืื™.

ืื™ืš ืงื•ืœื’ืŸ ื˜ื‘ืขื•ื ื™ ืขื•ื‘ื“?

ืงื•ืœื’ืŸ ื˜ื‘ืขื•ื ื™ ืขื•ื‘ื“ ื‘ืื•ืคืŸ ื“ื•ืžื” ืœืชื•ืกืคื™ ืงื•ืœื’ืŸ ืœื ื˜ื‘ืขื•ื ื™ื™ื. ืœืื—ืจ ื ื˜ื™ืœื” ืฉืœ ืชื•ืกืฃ ืงื•ืœื’ืŸ ื˜ื‘ืขื•ื ื™, ื—ื•ืžืฆื•ืช ื”ืืžื™ื ื• ื•ื”ื—ื•ืžืจื™ื ื”ืžื–ื™ื ื™ื ื”ืื—ืจื™ื ื ืกืคื’ื™ื ื‘ื’ื•ืฃ. ืœืื—ืจ ืžื›ืŸ ื”ื—ื•ืžืจื™ื ื”ืžื–ื™ื ื™ื ื”ืืœื” ืžื’ื™ืขื™ื ืืœ ื”ืขื•ืจ, ืฉื ื”ื ืขื•ื–ืจื™ื ืœื”ื’ื‘ื™ืจ ืืช ื™ื™ืฆื•ืจ ื”ืงื•ืœื’ืŸ. 

ื’ื ืฉื™ืžื•ืฉ ื—ื™ืฆื•ื ื™ ื‘ืชื›ืฉื™ืจื™ื ืขื ืงื•ืœื’ืŸ ื•ื’ื ื ื˜ื™ืœืช ื‘ื•ึผืกื˜ืจ ืฉืœ ืงื•ืœื’ืŸ ืขืฉื•ื™ื™ื ืœื”ื‘ื™ื ืชื•ืขืœืช. ื—ืฉื•ื‘ ืœืฆื™ื™ืŸ ื›ื™ ื ื˜ื™ืœืช ืชื•ืกืคื™ื ื•ืฉื™ืžื•ืฉ ื‘ืžื•ืฆืจื™ื ืขื ืงื•ืœื’ืŸ ื•ื˜ื‘ืขื•ื ื™ ืœื ื™ื‘ื™ืื• ืœืฉื™ื ื•ื™ ื‘ื”ืจื›ื‘ ื”ืขื•ืจ ื‘ื™ืŸ ืœื™ืœื”. ื–ื” ืชื”ืœื™ืš ืžืชืžืฉืš, ื›ืžื• ื›ืœ ื”ื“ื‘ืจื™ื ื”ื˜ื•ื‘ื™ื ื‘ื—ื™ื™ื. 

ืงื•ืœื’ืŸ ื˜ื‘ืขื•ื ื™ ื‘ืงื•ืกืžื˜ื™ืงื”

ื›ื›ืœ ืฉืžื“ืขื ื™ื ืžืคืชื—ื™ื ืชื—ืœื™ืคื™ ืงื•ืœื’ืŸ ืœืœื ืžืจื›ื™ื‘ื™ื ืžืŸ ื”ื—ื™, ืงื•ืœื’ืŸ ื˜ื‘ืขื•ื ื™ ื–ื•ื›ื” ืœืคื•ืคื•ืœืจื™ื•ืช ื”ื•ืœื›ืช ื•ื’ื•ื‘ืจืช ื›ืžืจื›ื™ื‘ ืฉืœ ืžื•ืฆืจื™ ืงื•ืกืžื˜ื™ืงื” ื›ืžื• ืงืจื ืขื™ื ื™ื™ื, ืงืจื ืœื™ืœื” ื•ืืคื™ืœื• ืกืจื•ื. ืžื•ืฆืจื™ ื”ืงื•ืกืžื˜ื™ืงื” ื”ืืœื” ื™ื›ื•ืœื™ื ืœื”ื›ื™ืœ ืงื•ืœื’ืŸ ื˜ื‘ืขื™ ืื• ื‘ื•ึผืกื˜ืจื™ื ืฉืœ ืงื•ืœื’ืŸ. ื–ื” ืขื•ื–ืจ ืœืฆืžืฆื ืืช ื”ื•ืคืขืชื ืฉืœ ืงืžื˜ื•ื˜ื™ื ื•ืงืžื˜ื™ื. 

ืžื•ืฆืจื™ ืงื•ืกืžื˜ื™ืงื” ืžืกื•ื™ืžื™ื ืขื ืงื•ืœื’ืŸ ื˜ื‘ืขื•ื ื™ ืžื™ื•ืฆืจื™ื ืžืืฆื•ืช ื™ื. ื‘ื•ึผืกื˜ืจื™ื ืฉืœ ืงื•ืœื’ืŸ ืžืžืงื•ืจ ืฆืžื—ื™ ืžื›ื™ืœื™ื ื“ื•ื‘ื“ื‘ื ื™ ื‘ืจื‘ื“ื•ืก (ืืกืจื•ืœื”), ื•ื™ื˜ืžื™ืŸ C ื•ื•ื™ื˜ืžื™ืŸ E ื•ื’ื ื—ื•ืžืฆื” ื”ื™ืืœื•ืจื•ื ื™ืช

ื™ืชืจื•ื ื•ืช ื‘ืจื™ืื•ืชื™ื™ื ืฉืœ ืงื•ืœื’ืŸ ื˜ื‘ืขื•ื ื™

ืชื•ืกืคื™ ืงื•ืœื’ืŸ ื˜ื‘ืขื•ื ื™ ืขื“ื™ื™ืŸ ื ืžืฆืื™ื ื‘ืฉืœื‘ื™ ืคื™ืชื•ื— ืžื•ืงื“ืžื™ื, ืื‘ืœ ื ื™ืชืŸ ืœื”ืฉื™ื’ ืžื•ืฆืจื™ ืงื•ืกืžื˜ื™ืงื” ืฉืžื›ื™ืœื™ื ืงื•ืœื’ืŸ ื˜ื‘ืขื•ื ื™. ืžื•ืฆืจื™ื ืืœื” ืžืฆื™ืขื™ื ืฉื•ืจื” ืฉืœ ื™ืชืจื•ื ื•ืช, ื—ืœืงื ื–ื”ื™ื ืœื™ืชืจื•ื ื•ืช ืฉืœ ืžื•ืฆืจื™ื ืขื ืงื•ืœื’ืŸ ืฉืื™ื ื• ื˜ื‘ืขื•ื ื™ ื•ื—ืœืงื ื™ื™ื—ื•ื“ื™ื™ื ืœืงื•ืœื’ืŸ ื˜ื‘ืขื•ื ื™. ื‘ื™ืŸ ืื•ืชื ื”ื™ืชืจื•ื ื•ืช ื”ืคื•ื˜ื ืฆื™ืืœื™ื™ื:

  • ืžืจืื” ืขื•ืจ ืฆืขื™ืจ ื™ื•ืชืจ: ืžืื—ืจ ืฉืงื•ืœื’ืŸ ื˜ื‘ืขื•ื ื™ ื™ื›ื•ืœ ืœืฆืžืฆื ื”ื•ืคืขืช ืงืžื˜ื™ื ื•ืœืฉืคืจ ืืช ื’ืžื™ืฉื•ืช ื”ืขื•ืจ, ื”ื•ื ืขืฉื•ื™ ืœื”ืขื ื™ืง ืœืขื•ืจ ืžืจืื” ืฆืขื™ืจ ื™ื•ืชืจ.
  • ืฆืžืฆื•ื ื”ื•ืคืขืช ืงืžื˜ื™ื ื•ืงืžื˜ื•ื˜ื™ื: ืงืจืžื™ื ืขื ืงื•ืœื’ืŸ ื˜ื‘ืขื•ื ื™ ืขืฉื•ื™ื™ื ืœืชืจื•ื ืœืฆืžืฆื•ื ื”ื•ืคืขืชื ืฉืœ ืงืžื˜ื™ื ื•ืงืžื˜ื•ื˜ื™ื ืขืœ ื”ืคื ื™ื, ื”ืฆื•ื•ืืจ ื•ื—ืœืงื™ ื’ื•ืฃ ืื—ืจื™ื. 
  • ืฉื™ืคื•ืจ ื’ืžื™ืจื•ืช ื”ืขื•ืจ: ืงื•ืœื’ืŸ ื˜ื‘ืขื•ื ื™ ืขืฉื•ื™ ืœืชืจื•ื ืœืฉื™ืคื•ืจ ื’ืžื™ืฉื•ืช ื”ืขื•ืจ. ื–ื” ื™ื›ื•ืœ ืœืฆืžืฆื ืืช ืจืคื™ื•ืŸ ื”ืขื•ืจ ื•ืœื”ืขื ื™ืง ืœืขื•ืจ ืžืจืื” ืžืชื•ื— ื•ืžื•ืฆืง ื™ื•ืชืจ. 
  • ื”ื’ื‘ืจืช ื™ื™ืฆื•ืจ ื”ืงื•ืœื’ืŸ: ื™ืฉ ืœืžื•ืฆืจื™ื ืขื ืงื•ืœื’ืŸ ื˜ื‘ืขื•ื ื™ ืกื’ื•ืœื•ืช ืฉืขืฉื•ื™ื•ืช ืœืชืจื•ื ืœื”ื’ื‘ืจืช ื™ื™ืฆื•ืจ ื”ืงื•ืœื’ืŸ ื”ื˜ื‘ืขื™ ื‘ื’ื•ืฃ.

ื”ืื ืื ื• ื–ืงื•ืงื™ื ืœืงื•ืœื’ืŸ?

ื™ืฉ ืœืงื•ืœื’ืŸ ืชืคืงื™ื“ ื—ืฉื•ื‘ ื‘ื’ื•ืฃ ื”ืื“ื. ื–ื” ื”ื—ืœื‘ื•ืŸ ื”ื ืคื•ืฅ ื‘ื™ื•ืชืจ ื‘ืขื•ืจ ื•ืžืจื›ื™ื‘ ื—ืฉื•ื‘ ืฉืœ ื”ืขืฆื, ื”ืขื•ืจ, ื”ืฉืจื™ืจื™ื, ื”ื’ื™ื“ื™ื ื•ื”ืกื—ื•ืก. ื›ื›ืœ ืฉืื ื• ืžื–ื“ืงื ื™ื, ื™ื™ืฆื•ืจ ื”ืงื•ืœื’ืŸ ื”ื˜ื‘ืขื™ ื‘ื’ื•ืฃ ืคื•ื—ืช, ื•ื”ืงื•ืœื’ืŸ ื”ืงื™ื™ื ืžืชื—ื™ืœ ืœื”ืชืคืจืง. ื–ื” ืขืœื•ืœ ืœื”ื•ื‘ื™ืœ ืœื”ื•ืคืขืช ืกื™ืžื ื™ ื”ื–ื“ืงื ื•ืช, ื›ืžื• ืงืžื˜ื™ื ื•ืงืžื˜ื•ื˜ื™ื. 

ืงืžื˜ื™ื ื•ืงืžื˜ื•ื˜ื™ื ื”ื ื—ืœืง ื˜ื‘ืขื™ ืžืชื”ืœื™ืš ื”ื”ื–ื“ืงื ื•ืช, ื•ืœื ืžืฉื”ื• ืฉืฆืจื™ืš "ืœืชืงืŸ". ืขื ื–ืืช, ืื ื”ืงืžื˜ื™ื ื•ื”ืงืžื˜ื•ื˜ื™ื ืžืคืจื™ืขื™ื ืœื›ื, ื›ื“ืื™ ืœื“ืขืช ื›ื™ ืงื•ืœื’ืŸ ืขืฉื•ื™ ืœืชืจื•ื ืœืฉื™ืคื•ืจ ื”ืžืจืื” ื”ื›ืœืœื™ ืฉืœ ื”ืขื•ืจ ื•ืœืชืช ืœื• ืžืจืื” ืฆืขื™ืจ ื™ื•ืชืจ.

ืืžื ื ืื™ืŸ ื›ืœ ืงื•ืฉื™ ืœื”ืฉื™ื’ ืงื•ืœื’ืŸ ืžืŸ ื”ื—ื™, ืื‘ืœ ื™ืฉ ืžืกืคืจ ืกื™ื‘ื•ืช ืœื›ืš ืฉืื ืฉื™ื ืื•ืœื™ ืจื•ืฆื™ื ืœืฉืงื•ืœ ืงื•ืœื’ืŸ ืžืžืงื•ืจื•ืช ื˜ื‘ืขื•ื ื™ื™ื. ืงื•ืœื’ืŸ ื˜ื‘ืขื•ื ื™ ื ื”ื™ื” ื™ื•ืชืจ ื•ื™ื•ืชืจ ืคื•ืคื•ืœืจื™, ื›ื›ืœ ืฉืื ืฉื™ื ืžื—ืคืฉื™ื ืชื•ืกืคื™ ืงื•ืœื’ืŸ ืœืœื ืžืจื›ื™ื‘ื™ื ืžืŸ ื”ื—ื™. 

ื™ืฉ ื“ืจื›ื™ื ืจื‘ื•ืช ืœื”ื’ื‘ื™ืจ ืืช ื™ื™ืฆื•ืจ ื”ืงื•ืœื’ืŸ ื‘ื’ื•ืฃ: ืชื–ื•ื ื”, ืื•ืจื— ื—ื™ื™ื ื•ื’ื•ืจืžื™ื ืกื‘ื™ื‘ืชื™ื™ื, ืœืฆื“ ืžื•ืฆืจื™ ืงื•ืœื’ืŸ. ืžื–ื•ื ื•ืช ืฆืžื—ื™ื™ื ื›ืžื• ืคื™ืจื•ืช ื•ื™ืจืงื•ืช ื”ื ืžืจื›ื™ื‘ ื—ื™ื•ื ื™ ืฉืœ ื”ืชื–ื•ื ื”, ืฉื›ืŸ ื”ื ืขื•ื–ืจื™ื ืœืฉืžื•ืจ ืขืœ ืžืื’ืจื™ ื”ืงื•ืœื’ืŸ.5 ื›ืžื• ืชืžื™ื“ ื‘ืชื—ื•ื ื”ื‘ืจื™ืื•ืช ื•ื”ืจื•ื•ื—ื” ื”ื›ืœืœื™ืช, ื—ืฉื•ื‘ ืœื‘ื—ื•ืจ ื‘ื’ื™ืฉื” ื”ืžืชืื™ืžื” ื‘ื™ื•ืชืจ ืขื‘ื•ืจื›ื. 

ื”ืคื ื™ื•ืช:

  1. Bรกez J, Olsen D, Polarek JW. Recombinant microbial systems for the production of human collagen and gelatin. Applied Microbiology and Biotechnology 2005 69:3. 2005;69(3):245-252. doi:10.1007/S00253-005-0180-X
  2. Shuster S. Osteoporosis, like skin ageing, is caused by collagen loss which is reversible. J R Soc Med. 2020;113(4):158. doi:10.1177/0141076820910315
  3. DePhillipo NN, Aman ZS, Kennedy MI, Begley JP, Moatshe G, LaPrade RF. Efficacy of Vitamin C Supplementation on Collagen Synthesis and Oxidative Stress After Musculoskeletal Injuries: A Systematic Review. Orthopaedic Journal of Sports Medicine. 2018;6(10). doi:10.1177/2325967118804544
  4. Harris ED, Rayton JK, Balthrop JE, DiSilvestro RA, Garcia-de-Quevedo M. Copper and the synthesis of elastin and collagen. Ciba Found Symp. 1980;79:163-182. doi:10.1002/9780470720622.CH9
  5. Solway J, McBride M, Haq F, Abdul W, Miller R. Diet and Dermatology: The Role of a Whole-food, Plant-based Diet in Preventing and Reversing Skin Agingโ€”A Review. The Journal of Clinical and Aesthetic Dermatology. 2020;13(5):38.

โ€‹ื›ืชื‘ ื•ื™ืชื•ืจ:โ€‹ ืžืจื›ื– ื”ื‘ืจื™ืื•ืช ื”ื–ื” ืœื ื ื•ืขื“ ืœืื‘ื—ืŸ,,, โ€‹ื”ืฆื’ ืขื•ื“